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Lexington, KY 40511
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Faculty And Section Heads > Dr. Erdal Erol
Erdal Erol, DVM, MS, PhD
Professor, Head, Clinical Microbiology
DVM – Firat University
MS – University of Missouri
PhD – Texas A&M University
Areas of Interest:
Diagnostic assays, Antimicrobial resistance, Infectious disease investigation, Rhodococcus equi
equi is a facultative intracellular bacterium causing
pyogranulomatous pneumonia with abscessation in young foals as well as
opportunistic pyogranulomatous infections in humans and some other animals such
as ruminants, pigs, cats and dogs. R. equi can also cause
abdominal abscesses or septic arthritis with or without pulmonary disease in
foals. My laboratory has recently focused on increased resistance to rifampin
and macrolides, which are considered as mainstay dual treatment against R.
equi infections in foals. In a new study containing necropsied
foals with rhodococcosis, we confirmed this trend of increased dual resistance in necropsied foals treated with mainstay dual therapy. In addition, we demonstrated that R.
equi isolates with pREerm46 significantly increased MICs for trimethoprim- sulfamethoxazole and doxycycline in addition to macrolides. Despite dual therapy, increased resistance against rifampin and
macrolides warrants evaluation of new treatment protocols in foals. Currently
we are investigating some other drugs in laboratory conditions against
rifampin- and macrolides-resistant R. equi isolates.
1- Antimicrobial resistance spectrum conferred by pREerm46 of emerging macrolide (multidrug)-resistant Rhodococcus equi. Erol E., Scortti M., Fortner J., Patel M., Vazquez-Boland JA. Journal of Clinical Microbiology, (Impact Factor: 5.897) Accepted. 2021
2- Identification of ruminant origin Group B Rotavirus associated with diarrhea outbreaks in foals. Uprety T, Sreenivasan CC, Hause BM, Li G, Odemuyiwa SO, Locke S, Morgan J, Zeng L, Gilsenan WF, Slovis N, Metcalfe L, Carter CN, Timoney P, Horohov D, Wang D, Erol E, Adam E, Li F. Viruses (Impact Factor : 3.816). Accepted. 2021
3- Antimicrobial susceptibility patterns of Rhodococcus equi from
necropsied foals with rhodococcosis. E. Erol, S. Locke, A. Saied, M. Cruz Penn,
J. Smith and C. Carter. Veterinary Microbiology. (Impact Factor: 3.293)
4- Development and evaluation of a one-step
real-time multiplex TaqMan® RT-qPCR assay for the detection and genotyping of
equine G3 and G14 rotaviruses in fecal samples. Mariano Carossino; Maria
Barrandeguy; Erdal Erol; Yanqiu Li; Udeni Balasuriya*, Virology Journal (Impact
factor: 2.468), 2019 Apr 25;16(1):49. doi: 10.1186/s12985-019-1149-51
5- Temporal trends and predictors of antimicrobial resistance amongStaphylococcus spp.
isolated from canine specimens submitted to a diagnostic laboratory. Conner JG,
Smith J, Erol E, Locke S, Phillips E, Carter CN, Odoi A*. PLoS One (Impact
factor: 2.468), 2018 Aug 1;13(8):e0200719.
6- Emergence of resistance to macrolides and rifampicin in clinical isolates
of Rhodococcus equi from foals in central Kentucky, USA: 1995
to 2017. Laura Huber, Steeve Giguere, Nathan Slovis, Craig Carter,
Bonnie Barr, Noah Cohen*, Justine Elam, Erdal Erol, Stephan Locke, Erica
Phillips, and Jacqueline Smith. Antimicrobial agents and chemotherapy (Impact
factor: 4.715), 63 (1), e01714-18
7- Elevated serum amyloid A levels in cases of
aborted equine fetuses due to fetal and placental infections. Erol E,
Jackson C, Horohov D, Locke S, Smith J, Carter C. Theriogenology. (Impact Factor: 2.094) 86(4); 971-975. 2016
8-Beta-hemolytic Streptococcus dysgalactiae strains isolated
from horses are a genetically distinct population within the Streptococcus
dysgalactiae taxon. Pinho MD, Erol E, Ribeiro-Gonçalves B,
Mendes CI, Carriço JA, Matos SC, Preziuso S, Luebke-Becker A, Wieler LH,
Melo-Cristino J, Ramirez M. Sci Rep. (Impact Factor: 4.379) 2016 Aug 17;6:31736. doi:
9- Antimicrobial susceptibility of Rhodococcus
equi of animal origin. Anne Riesenberg, Andrea T. Feßler, Erdal Erol,
Ellen Prenger-Berninghoff, Yvonne Stamm, Urte Menke, Anton Heusinger,
Dieter Klarmann, Stefan Schwarz, Christiane Werckenthin J.
Antimicrob Chemother. (Impact Factor: 5.439) 2014 Apr;69(4):1045-9.